Transforming the Blood Collection Tube market

Australian scientists have found a way to use components of snake venom to improve an essential clinical tool which will assist in optimising laboratory efficiency, clinical diagnosis and patient care.

The venom of some snakes (including the Australian Taipan) has a potent ability to coagulate the blood of mammals including humans and it is this ability which caught the interest of a group of Queensland medical scientists and pathologists. The team isolated the potent clotting proteins and used them to develop superior blood collection tubes.

Q-Sera tubes contain highly potent prothrombin activators found in nature in snake venom

Snake-derived prothrombin activators have adapted to clot mammalian systems and bypass or overcome coagulation control systems - clot to completion.

Serum is the gold standard for biochemical analysis of blood samples and is produced when blood clots. Current tubes use a clot activator but in many instances are unable to clot the blood of some patients – such as anticoagulated cardiac patients or those taking common medicine such as warfarin or other oral anticoagulants.

The prevalence of anticoagulant use is increasing in the general community and hospital populations. Q-Sera’s technology has been developed to meet these needs and produce a quality serum sample in the shortest time possible from anticoagulated blood.

ACTIVE – RAPClot

Q-Sera has developed a lead ‘recombinant’ protein, RAPClot, which is manufactured from modified cell lines using standard pharmaceutical manufacturing processes. High yielding and high purity RAPClot has been developed using these techniques for low cost use in blood collection tubes.

As a recombinantly manufactured protein, supply of RAPClot is not limited. In line with standard practice, RAPClot can be manufactured at GMP Quality level

ACTIVE – OsPA

Q-Sera has a naturally-sourced active which is fractionated from the venom of the Coastal Taipan snake (Oxyuranus scutellatus). The Coastal Taipan is one of the world’s most venomous snakes and is found in North East Australia and Papua New Guinea. The prothrombin activator extracted from the Taipan’s venom is a complex of Coagulation Factor Va (FVa) and Coagulation Factor Xa (FXa) – like proteins isolated via one step gel chromatography and is known as ‘OsPA’.

Supply of OsPA for up to the largest volume market segments can be sourced from Taipan snakes as a reliable, scalable natural source. OsPA can be produced at GMP Quality level if required.